Pamiparib hydrate

• Catalog Number: orb1739365
• Category: Small Molecules
• Description: Pamiparib hydrate
• CAS Number: 1858211-28-5
• Purity: 0.98
• MW: 352.36
• SMILES: O.C[C@]12CCCN1Cc1n[nH]c(=O)c3cc(F)cc4[nH]c2c1c34
• Formula: C₁₆H₂₁FN₄O₄
• Biological Activity: Pamiparib, also known as BGB-290, is a highly potent and selective PARP inhibitor with favorable drug metabolism and pharmacokinetic properties. BGB-290 selectively binds to PARP and prevents PARP-mediated repair of single-strand DNA breaks via the base-excision repair (BER) pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability, and eventually leads to apoptosis. BGB-290 may both potentiate the cytotoxicity of DNA-damaging agents and reverse tumor cell chemo- and radioresistance.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.