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Catalog Number | orb1823525 |
---|---|
Category | Antibodies |
Description | p63 is a homolog of the tumor suppressor p53. It is identified in basal cells in the epithelial layers of a variety of tissues, including epidermis, cervix, urothelium, breast and prostate. p63 was detected in nuclei of the basal epithelium in normal prostate glands; however, it was not expressed in malignant tumors of the prostate. As a result, p63 has been reported as a useful marker for differentiating benign from malignant lesions in the prostate, particularly when used in combination with markers of high molecular weight cytokeratins and the prostate-specific marker AMACR (P504S). p63 has also been shown to be a sensitive marker for lung squamous cell carcinomas (SqCC), with a sensitivity of ~90%. Specificity for lung SqCC, vs. lung adenocarcinoma (LADC), is approximately 80%. In breast tissue, p63 has been identified in myoepithelial cells of normal ducts. |
Species/Host | Mouse |
Clonality | Recombinant |
Clone Number | rP40/8765 |
Tested applications | IHC-P |
Reactivity | Human |
Isotype | Mouse IgG2a, kappa |
Immunogen | A recombinant partial protein sequence (within amino acids 1-200) from the human protein was used as the immunogen for the p63 antibody. |
Dilution range | Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT |
Conjugation | Unconjugated |
Formula | 1 mg/ml in 1X PBS; BSA free, sodium azide free |
Hazard Information | This p63 antibody is available for research use only. |
UniProt ID | Q9H3D4 |
Storage | Aliquot the p63 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles. |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
IHC staining of FFPE human prostate cancer tissue with p63 antibody (clone rP40/8765). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
SDS-PAGE analysis of purified, BSA-free p63 antibody (clone rP40/8765) as confirmation of integrity and purity.
FACS, IHC-P | |
Human | |
Mouse | |
Monoclonal | |
Unconjugated |
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