OTS186935

• Catalog Number: orb573120
• Category: Small Molecules
• Description: OTS186935 (OTS-186935) is a potent, in vivo-active inhibitor of protein methyltransferase SUV39H2 with IC50 of 6.49 nM, inhibits A549 cell growth with IC50 of 0.67 uM; causes a significant growth inhibitory effect in mouse xenograft models using MDA-MB-231 breast cancer cells as well as A549 lung cancer cells, at 25 mg/kg once daily for 14 days yielded a TGI of 60.8%; attenuates the levels of H3K9me3 in A549 xenograft mouse model.
• CAS Number: [2093400-18-9]
• MW: 463.966
• SMILES: N(C1C=CN2C=C(C3=CC(Cl)=C(OC)C=C3OC)N=C2C=1)1CC[C@@H](NCC2C=CN=CC=2)C1
• Formula: C₂₅H₂₆ClN₅O₂
• Note: For research use only
• Expiration Date: 12 months from date of receipt.