ONO-7475

• Catalog Number: orb654586
• Category: Small Molecules
• Description: ONO-7475 is a potent, selective, and orally active novel Anexelekto/MER tyrosine kinase inhibitor with IC50 values of 0.7 nM and 1.0 nM, respectively. ONO-7475 sensitizes AXL-overexpressing EGFR-mutant NSCLC cells to the EGFR-TKIs, suppresses the emergence and maintenance of tolerant cells. ONO-7475 combines with Osimertinib (HY-15772) provides a bright promise for the study of EGFR-mutated non-small cell lung cancer (NSCLC).
• CAS Number: [1646839-59-9]
• MW: 562.57
• SMILES: O=C(NC1C=CC(OC2C3C(=CC(=C(C=3)OC)OC)N=CC=2)=CN=1)C1C(=O)N(C2C=CC=CC=2)C2CCCC(=O)C=2C=1
• Formula: C₃₂H₂₆N₄O₆
• Note: For research use only
• Expiration Date: 12 months from date of receipt.