O-Demethyl Apremilast

• Catalog Number: orb1694190
• Category: Small Molecules
• Description: O-Demethyl Apremilast
• CAS Number: 1384441-38-6
• Purity: 98%
• MW: 446.47
• SMILES: CCOc1cc(ccc1O)[C@@H](CS(C)(=O)=O)N1C(=O)c2cccc(NC(C)=O)c2C1=O
• Formula: C₂₁H₂₂N₂O₇S
• Biological Activity: O-Demethyl apremilast is an active metabolite of the phosphodiesterase 4 (PDE4) inhibitor apremilast .1It inhibits the activity of PDE4 isolated from U937 cells and LPS-induced TNF-α production in isolated human peripheral blood mononuclear cells (PBMCs; IC50s = 8.3 and 5.6 μM, respectively). O-Demethyl apremilast is also an oxidative degradation product of apremilast.2,3
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.