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NVS-ZP7-4
Catalog Number: orb654612
| Catalog Number | orb654612 |
|---|---|
| Category | Small Molecules |
| Description | NVS-ZP7-4 is a potent ZIP7 Inhibitor, which inhibits Notch signaling with IC50 of 0.13 uM in HES-Luc reporter gene assays, selectively induces apoptosis and ER stress. NVS-ZP7-4 altered zinc in the ER, and an analog of the compound photoaffinity labeled ZIP7 in cells, suggesting a direct interaction between the compound and ZIP7. NVS-ZP7-4 is the first reported chemical tool to probe the impact of modulating ER zinc levels and investigate ZIP7 as a novel druggable node in the Notch pathway. |
| CAS Number | [2349367-89-9] |
| Purity | > 98%,Standard References |
| MW | 501.618227958679 |
| SMILES | O=C1NC2C=CC=CC=2C2(CCN(C[C@H](CC3C=CC=CC=3)NC3SC4C(=CC=C(C=4)F)N=3)CC2)N1 |
| Formula | C28H28FN5OS |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
NVS-ZP7-4 [orb1309309]
98.41%
2349367-89-9
501.62
C28H28FN5OS
25 mg, 1 mg, 10 mg, 50 mg, 5 mg, 100 mg, 2 mg, 1 ml x 10 mm (in DMSO)
