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Catalog Number | orb1300615 |
---|---|
Category | Small Molecules |
Description | Nutlin-3b |
CAS Number | 675576-97-3 |
Purity | 98.83% |
MW | 581.49 |
SMILES | C(=O)(N1[C@H]([C@H](N=C1C2=C(OC(C)C)C=C(OC)C=C2)C3=CC=C(Cl)C=C3)C4=CC=C(Cl)C=C4)N5CC(=O)NCC5 |
Formula | C30H30Cl2N4O4 |
Biological Activity | Nutlin-3b ((+)-Nutlin-3) is a p53/MDM2 antagonist or inhibitor (IC50: 13.6 μM), 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a. |
Storage | Store at -20°C for 12 months. |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
> 98% (HPLC) | |
675576-97-3 |
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