Nurr1 inverse agonist-1

SKU: orb1944662

Description

Nurr1 inverse agonist-1 is a indole-based inverse agonist targeting the neuroprotective transcription factor Nurr1, which plays a pivotal role in dopaminergic neuron regulation. Nurr1 inverse agonist-1 decreases the receptor's intrinsic transcriptional activity by up to more than 90% and revealed preference for inhibiting Nurr1 monomer activity. Nurr1 inverse agonist-1 enables the mechanistic study of Nurr1-mediated gene repression and the exploration of its potential implications in neurodegenerative disorders such as Parkinson’s disease.

Research Area

Metabolism Research

Key Properties

• CAS Number: 2758673-07-1
• MW: 266.29
• Formula: C₁₆H₁₄N₂O₂
• SMILES: O=C(OC)C1=CN(C2=CC=C(C=C12)C=3C=NC=CC3)C
• Target: NR4A,Others
• Solubility: DMSO:80 mg/mL (300.42 mM)

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

162640920