NSC697923

• Catalog Number: orb1685641
• Category: Small Molecules
• Description: NSC697923
• CAS Number: 343351-67-7
• Purity: 99.31%
• MW: 267.26
• SMILES: S(=O)(=O)(C=1OC(N(=O)=O)=CC1)C2=CC=C(C)C=C2
• Formula: C₁₁H₉NO₅S
• Biological Activity: NSC-697923 (2-[(4-methylphenyl)sulfonyl]-5-nitrofuran), a potent inhibitor of UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13), exhibits its role in inducing cell death in neuroblastoma (NB) cells through two distinct mechanisms. In p53 wild-type NB cells, NSC-697923 promotes the nuclear importation of p53, thereby triggering cell death. Meanwhile, in p53 mutant NB cells, NSC-697923 activates the JNK-mediated apoptotic pathway, leading to cell death. Additionally, NSC-697923 inhibits DNA damage and NF-κB signaling, further contributing to its antitumor activity.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.