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Catalog Number | orb1298032 |
---|---|
Category | Small Molecules |
Description | NS3861 |
CAS Number | 216853-59-7 |
Purity | 99.40% |
MW | 284.22 |
SMILES | BrC1=C(SC=C1)C=2CC3N(C)C(C2)CC3 |
Formula | C12H14BrNS |
Biological Activity | NS3861 is an agonist of nicotinic acetylcholine receptors (nAChRs) and bind with high affinity to heteromeric α3β4 and α4β2 nAChRs. NS3861 displays the β-subunit preference and a complete lack of activation at α4-containing receptors. The maximal efficacy of NS3861 appeared solely dependent on the nature of the ligand-binding domain. Furthermore, a principal subunit serine to threonine substitution may explain the lack of NS3861 activation at α4-containing receptors. |
Storage | Store at -20°C for 12 months. |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
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