NS13001

• Catalog Number: orb1307949
• Category: Small Molecules
• Description: NS13001
• CAS Number: 1063331-94-1
• Purity: 99.55%
• MW: 353.81
• SMILES: N(C1=C2C(=NC(=N1)N3N=C(C)C=C3C)N(C)C=N2)C4=CC=C(Cl)C=C4
• Formula: C₁₇H₁₆ClN₇
• Biological Activity: NS13001 (N-(4-Chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-9-methyl-9H-purin-6-amine) is a potent, selective, orally active allosteric positive modulator of SK channels (small conductance calcium-activated potassium channels). The EC50s are 1.8 and 0.14 μM for SK2 and SK3, respectively. NS13001 holds promise as a potential therapeutic agent for treatment of spinocerebellar ataxia type 2 (SCA2) and possibly other cerebellar ataxias.
• Storage: Store at -20°C for 12 months.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.