NP-12

• Catalog Number: orb1172433
• Category: Proteins
• Description: PD-1 - PD-L1 interaction blocker; Peptides.
• CAS Number: 1353563-85-5
• Modifications: C terminal amide, amide bridge between Lys-8 and Phe-7 in branch chain.
• Structure: H-Ser-Asn-Thr-Ser-Glu-Ser-Phe-Lys(H-Ser-Asn-Thr-Ser-Glu-Ser-Phe)-Phe-Arg-Val-Thr-Gln-Leu-Ala-Pro-Lys-Ala-Gln-Ile-Lys-Glu-NH2
• Target Areas: Protein-protein interactions
• Form/Appearance: Freeze dried solid
• Purity: > 95% by hplc
• MW: 3261.55 Da
• Formula: C₁₄₂H₂₂₆N₄₀O₄₈
• Solubility (25°C): Soluble in water
• Protein Sequence: H-Ser-Asn-Thr-Ser-Glu-Ser-Phe-Lys(H-Ser-Asn-Thr-Ser-Glu-Ser-Phe)-Phe-Arg-Val-Thr-Gln-Leu-Ala-Pro-Lys-Ala-Gln-Ile-Lys-Glu-NH2
• Storage: Store dry, frozen and in the dark
• Alternative names: 1353563-85-5, AUNP 12, AUR 012, NP-12, NP12, PD-1-
• Background: NP-12 is a branched peptide designed from analysis of the strands and loops of programmed cell death protein 1 (PD-1) at the interface of the PD-1/ programmed cell death ligand 1 (PD-L1) interaction. NP-12 binds to PD-L1 and is a functional equipotent antagonist of both PD-L1 and PD-L2 signaling. In preclinical models of melanoma, coloncancer, and kidney cancers, NP-12 showed significant efficacyin inhibiting primary tumour growth and metastasis. NP-12 shows antitumour activity in pre-established tumour modelseither as a single agent or when in combination with other immunologic cell death agents.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.