NLX-204

• Catalog Number: orb1910346
• Category: Small Molecules
• Description: NLX-204 is a potent and selective ERK1/2 phosphorylation-preferring serotonin 5 HT1A receptor agonist with pKi = 10.19. NLX-204 displayed high selectivity in the SafetyScreen44 panel (including hERG channel), high solubility, metabolic stability, and Caco-2 penetration and did not block CYP3A4, CYP2D6 isoenzymes, or P-glycoprotein. Preliminary in vivo studies confirmed its promising pharmacokinetic profile. NLX-204 also robustly stimulated ERK1/2 phosphorylation in rat cortex and showed highly potent (MED = 0.16 mg/kg) and efficacious antidepressant-like activity, totally eliminating immobility in the rat Porsolt test.
• CAS Number: [2170405-10-2]
• MW: 409.862
• SMILES: C(C1=CC=C(F)C(Cl)=C1)(N1CCC(F)(CNCCOC2=NC=CC=C2)CC1)=O
• Formula: C₂₀H₂₂ClF₂N₃O₂
• Note: For research use only
• Expiration Date: 12 months from date of receipt.