NIK inhibitor 4f(NIK SMI1)

• Catalog Number: orb746350
• Category: Small Molecules
• Description: NIK SMI1 is a potent, selective small molecule inhibitor of NF-κB inducing kinase (NIK) with Ki of 230±170 pM; only inhibits 3 out of 222 off-target kinases (KHS1, LRRK2, and PKD1) with > 75% inhibition at 1 uM; potently inhibits anti-LTβR-induced nuclear p52 levels in anti-LTβR-stimulated HeLa cells, with no effect on canonical signaling; inhibits BAFF and CD40 signaling, suppresses immune responses in vivo; suppresses disease biomarkers and improves survival and renal function in NZB/W F1 mice.
• CAS Number: [1660114-31-7]
• MW: 365.38
• SMILES: C(C(N)=O)1=NC(C2=CC=CC(C#C[C@](O)3CCN(C)C3=O)=C2)=CC(OC)=C1
• Formula: C₂₀H₁₉N₃O₄
• Note: For research use only
• Expiration Date: 12 months from date of receipt.