NEO214

• Catalog Number: orb2565692
• Category: Small Molecules
• Description: NEO214, an autophagy inhibitor and a covalent conjugate of the PDE4 inhibitor Rolipram and perillyl alcohol, exhibits anti-cancer activity and blood-brain barrier (BBB) permeability. It prevents autophagy-lysosome fusion, blocking autophagic flux and triggering glioma cell death via mTOR activation and TFEB (Transcription Factor EB) aggregation. NEO214 inhibition of Macroautophagy/autophagy in glioblastoma cells may overcome chemotherapy resistance in glioblastoma [1].
• CAS Number: 1361198-80-2
• Purity: 98.00%
• MW: 453.57
• SMILES: C(OCC=1CC[C@H](C(C)=C)CC1)(=O)N2CC(CC2=O)C3=CC(OC4CCCC4)=C(OC)C=C3
• Formula: C₂₇H₃₅NO₅
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.