NecroX-7

• Catalog Number: orb1685186
• Category: Small Molecules
• Description: NecroX-7
• CAS Number: 1120332-55-9
• Purity: 98%
• MW: 439.57
• SMILES: N(C1=C2C(C=C(N2)C3=CC=CC=C3)=CC(CN4CCS(=O)(=O)CC4)=C1)C5CCOCC5
• Formula: C₂₄H₂₉N₃O₃S
• Biological Activity: NecroX-7 (LC-280126) is a potent free radical scavenger and a HMGB1 (high-mobility group box 1) inhibitor. NecroX-7 can be used as an antidote to acetaminophen toxicity. NecroX-7 exerts a protective effect by preventing the release of HMGB1 in ischemia/reperfusion injury. Additionally, NecroX-7 inhibits the HMGB1-induced release of TNF and IL-6, as well as the expression of TLR-4 and receptor for advanced glycation end products. NecroX-7 may be use for treatment of graft-versus-host disease (GVHD) research [1].
• Note: For research use only
• Expiration Date: 12 months from date of receipt.