Necrostatin-5

• Catalog Number: orb1692789
• Category: Small Molecules
• Description: Necrostatin-5
• CAS Number: 337349-54-9
• Purity: 98%
• MW: 383.49
• SMILES: N#CCSC1=NC=2SC3=C(C2C(=O)N1C4=CC=C(OC)C=C4)CCCC3
• Formula: C₁₉H₁₇N₃O₂S₂
• Biological Activity: Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. Serine/threonine kinase activity of the death domain receptor-associated molecule RIP1 is thought to be essential for Fas ligand-induced and tumor necrosis factor-α (TNF-α) induced necrosis. Necrostatin-5 is a selective allosteric inhibitor of RIP1 kinase that prevents the death of TNF-α-treated FADD-deficient Jurkat cells with an EC50 value of 240 nM.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.