NB-598

• Catalog Number: orb1089420
• Category: Small Molecules
• Description: NB-598 is a potent competitive inhibitor of squalene epoxidase (SE). NB-598 suppresses triglyceride biosynthesis through the farnesol pathway. NB-598 suppresses the secretion of cholesterol and triacylglycerol and simultaneously reduces apolipoprotein B in HepG2 cells. NB-598 reduced basolaterally secreted radioactivity in cholesterol, cholesterol ester, PL and TG. Furthermore, NB-598 suppressed the basolateral secretion of apolipoprotein (apo) B. When microsomes prepared from control Caco-2 cells were incubated with 10 microM NB-598, acyl CoA:cholesterol acyltransferase (ACAT) activity was inhibited slightly.
• CAS Number: [131060-14-5]
• MW: 449.6711447
• SMILES: S1C(COC2=CC=CC(CN(C/C=C/C#CC(C)(C)C)CC)=C2)=CC(C2C=CSC=2)=C1
• Formula: C₂₇H₃₁NOS₂
• Note: For research use only
• Expiration Date: 12 months from date of receipt.