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NAB-14
Catalog Number: orb654644
| Catalog Number | orb654644 |
|---|---|
| Category | Small Molecules |
| Description | NAB-14 is a potent, selective negative allosteric modulator of GluN2C/2D-containing NMDA receptors with IC50 of 580 nM, > 800-fold selective over GluN2A/GluN2 receptors; inhibits triheteromeric (GluN1/GluN2A/GluN2C) NMDARs with modestly reduced potency and efficacy compared to diheteromeric (GluN1/GluN2C/GluN2C) receptors; inhibits GluN2D-mediated synaptic currents in rat subthalamic neurons and mouse hippocampal interneurons, but has no effect on synaptic transmission in hippocampal pyramidal neurons. |
| CAS Number | [1237541-73-9] |
| MW | 351.406 |
| SMILES | C(OC1=CC=C(C(=O)NC2C3=C(C=CC=2)C=CN3)C=C1)(=O)N(CC)CC |
| Formula | C20H21N3O3 |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
