Murine Oncostatin M protein

• Catalog Number: orb107791
• Category: Proteins
• Description: Recombinant Murine Oncostatin-M. Oncostatin-M (OSM) is a multifunctional cytokine that belongs to the Interleukin-6 subfamily. Among the family members, OSM is most closely related to leukemia inhibitory factor (LIF) and it in fact utilizes the LIF receptor in addition to its specific receptor in the human. A biologically active OSM receptor has been previously described that consists of a heterodimer of leukemia inhibitory factor receptor (LIFR) and gp130. OSM is synthesized by stimulated T-cells and monocytes. Furthermore, the effects of OSM on endothelial cells suggest a pro inflammatory role for OSM and endothelial cells possess a large number of OSM receptors. Recombinant murine OSM contains 181 amino acids and has a molecular mass of 20.4 kDa. It has approximately 48 % and 72 % amino acid sequence identity with human and rat OSM.
• Tested applications: HPLC, SDS-PAGE
• Purity: > 96 % by SDS-PAGE and HPLC analyses
• Conjugation: Unconjugated
• MW: 20.3 kDa
• Target: Oncostatin M
• Protein Sequence: NRGCSNSSSQ LLSQLQNQAN LTGNTESLLE PYIRLQNLNT PDLRAACTQH SVAFPSEDTLRQLSKPHFLS TVYTTLDRVL YQLDALRQKF LKTPAFPKLD SARHNILGIR NNVFCMARLLNHSLEIPEPT QTDSGASRST TTPDVFNTKI GSCGFLWGYH RFMGSVGRVF REWDDGSTRSR
• Biological Origin: E.coli
• Storage: Store at 4°C for up to two weeks. For long term storage, aliquot and store at -20°C, avoid freeze/thaw cycles.
• Buffer/Preservatives: Lyophilized from a 0.2 μm filtered concentrated solution in 2xPBS, pH 7.4, 5 % trehalose.
• Alternative names: Murine Oncostatin-M protein
• Note: For research use only
• Expiration Date: 6 months from date of receipt.

SDS-PAGE analysis of Murine Oncostatin M protein