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    MR1 Antibody / MHC class I related protein 1

    Catalog Number: orb1824326

    DispatchUsually dispatched within 5-10 working days
    $ 764.00
    Catalog Numberorb1824326
    CategoryAntibodies
    DescriptionMR1 (major histocompatibility complex, class I-related), also known as HLALS, is a 341 amino acid single-pass membrane protein that localizes to the endoplasmic reticulum, as well as to the extracellular side of the cell membrane, and contains one Ig-like C1-type domain. Expressed ubiquitously, MR1 exists as a heterodimer with b-2-Microglobulin and plays an important role in antigen presentation, specifically in the development and expansion of mucosalassociated invariant T cells (MAITs). MAITs are located in the gut and are involved in monitoring flora levels, as well as in conveying distress signals to other areas of the body, indicating a role for MR1 in proper digestion and immune system function. MR1 exists as four alternatively spliced isoforms and is encoded by a gene which maps to human chromosome 1.
    Species/HostMouse
    ClonalityMonoclonal
    Clone NumberMR1/7579
    Tested applicationsIHC-P
    ReactivityHuman
    IsotypeMouse IgG2, kappa
    ImmunogenA recombinant partial protein sequence (within amino acids 50-250) from the human protein was used as the immunogen for the MR1 antibody.
    Dilution rangeImmunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT
    ConjugationUnconjugated
    Formula1 mg/ml in 1X PBS; BSA free, sodium azide free
    Hazard InformationThis MR1 antibody is available for research use only.
    UniProt IDQ95460
    StorageAliquot the MR1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
    NoteFor research use only
    Expiration Date12 months from date of receipt.
    MR1 Antibody / MHC class I related protein 1

    IHC staining of FFPE human kidney tissue with MR1 antibody (clone MR1/7579). Inset: PBS used in place of primary Ab (secondary Ab negative control). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

    MR1 Antibody / MHC class I related protein 1

    SDS-PAGE analysis of purified, BSA-free MR1 antibody (clone MR1/7579) as confirmation of integrity and purity.

    • MR1 Antibody / MHC class I related protein 1 [orb1824327]

      IHC-P

      Human

      Mouse

      Monoclonal

      Unconjugated

      20 μg
    • MR1 Antibody / MHC class I related protein 1 [orb1824328]

      IHC-P

      Human

      Mouse

      Monoclonal

      Unconjugated

      100 μg
    • MR1 Antibody / MHC class I related protein 1 [orb1824332]

      IHC-P

      Human

      Mouse

      Monoclonal

      Unconjugated

      100 μg
    • MR1 Antibody / MHC class I related protein 1 [orb1824333]

      IHC-P

      Human

      Mouse

      Monoclonal

      Unconjugated

      20 μg
    • MR1 Antibody / MHC class I related protein 1 [orb1824334]

      IHC-P

      Human

      Mouse

      Monoclonal

      Unconjugated

      100 μg
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