MLi-2

• Catalog Number: orb1308022
• Category: Small Molecules
• Description: MLi-2
• CAS Number: 1627091-47-7
• Purity: 99.33%
• MW: 379.46
• SMILES: O(C=1C=C2C(=NNC2=CC1)C=3C=C(N=CN3)N4C[C@H](C)O[C@H](C)C4)C5(C)CC5
• Formula: C₂₁H₂₅N₅O₂
• Biological Activity: MLi-2 is a structurally novel, highly potent, and selective LRRK2 kinase inhibitor with central nervous system activity. MLi-2 exhibits exceptional potency in a purified LRRK2 kinase assay in vitro (IC50 = 0.76 nM), a cellular assay monitoring dephosphorylation of LRRK2 pSer935 LRRK2 (IC50 = 1.4 nM), and a radioligand competition binding assay (IC50 = 3.4 nM).
• Storage: Store at -20°C for 12 months.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.