ML417

• Catalog Number: orb692122
• Category: Small Molecules
• Description: ML417 is a Highly Selective D3 Dopamine Receptor Agonist. ML417 potently promotes D3R-mediated β-arrestin translocation, G protein activation, and ERK1/2 phosphorylation (pERK) while lacking activity at other dopamine receptors. Screening of ML417 against multiple G protein-coupled receptors revealed exceptional global selectivity. Molecular modeling suggests that ML417 interacts with the D3R in a unique manner, possibly explaining its remarkable selectivity. ML417 was also found to protect against neurodegeneration of dopaminergic neurons derived from iPSCs.
• CAS Number: [1386162-69-1]
• MW: 379.45
• SMILES: O=C(C(N1)=CC2=C1C=CC=C2)N3CCN(CCOC4=CC=C(OC)C=C4)CC3
• Formula: C₂₂H₂₅N₃O₃
• Note: For research use only
• Expiration Date: 12 months from date of receipt.