ML372

• Catalog Number: orb757658
• Category: Small Molecules
• Description: ML372 is a small molecule SMN modulator that increases SMN protein in patient fibroblasts with EC50 of 37 nM; possesses good potency, pharmacokinetics, tolerance, and CNS penetration that are able to increase levels of SMN protein in several model cell lines; increase SMN protein levels in vivo, restore motor function, and prolong survival of SMNΔ7 SMA Mice; improves the righting reflex and extended survival of a severe mouse model of SMA.
• CAS Number: [1331745-61-9]
• MW: 360.428
• SMILES: O=C(O)C(CC1)CCN1C2=NC=C(S2)C3=CC(OCCCO4)=C4C=C3
• Formula: C₁₈H₂₀N₂O₄S
• Note: For research use only
• Expiration Date: 12 months from date of receipt.