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Catalog Number | orb1308029 |
---|---|
Category | Small Molecules |
Description | ML-792 |
CAS Number | 1644342-14-2 |
Purity | 98.22% |
MW | 551.41 |
SMILES | NS(=O)(=O)OC[C@H]1C[C@H](C[C@@H]1O)Nc1ncncc1C(=O)c1ccn(Cc2cccc(Br)c2)n1 |
Formula | C21H23BrN6O5S |
Biological Activity | ML-792 is a specific small ubiquitin-like modifier (SUMO)-activating enzyme (SAE) inhibitor. Compared with NAE/NEDD8 and UAE/ubiquitin (IC50s of 32 μM and > 100 μM, respectively), ML-792 is an effective and selective inhibitor of SAE/SUMO1 and SAE/SUMO2 in enzymatic assays (IC50s of 3 and 11 nM, respectively). |
Storage | -20°C |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |