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Catalog Number | orb1146624 |
---|---|
Category | Small Molecules |
Description | MF-766 (MF766) is a highly potent and selective EP(4) antagonist with binding Ki of 0.23 nM, displays no significant affinity (>7000-fold selectivity) against other PG receptors (IC50>1500 nM); behaved as a full antagonist with an IC50 of 1.4 nM (shifted to 1.8 nM in the presence of 10% HS) in the functional assay; exhibits blockade of inhibition of TNFa-induced IP10 release by the specific EP4 agonist L-000902688 (IC50=9.5 nM); demonstrates potency and efficacy of in the rat AIA model measuring inhibition of paw swelling. |
CAS Number | [1050656-06-8] |
MW | 478.471 |
SMILES | O=C(O)C1=CC=C(C2(NC(C3=CC=CC4=C3N(CC5=CC=C(C(F)(F)F)C=C5)C=C4)=O)CC2)C=C1 |
Formula | C27H21F3N2O3 |
Hazard Information | Non-Toxic |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
98% | |
1050656-06-8 | |
478.46 | |
C27H21F3N2O3 |
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