MF-766

• Catalog Number: orb1146624
• Category: Small Molecules
• Description: MF-766 (MF766) is a highly potent and selective EP(4) antagonist with binding Ki of 0.23 nM, displays no significant affinity (>7000-fold selectivity) against other PG receptors (IC50>1500 nM); behaved as a full antagonist with an IC50 of 1.4 nM (shifted to 1.8 nM in the presence of 10% HS) in the functional assay; exhibits blockade of inhibition of TNFa-induced IP10 release by the specific EP4 agonist L-000902688 (IC50=9.5 nM); demonstrates potency and efficacy of in the rat AIA model measuring inhibition of paw swelling.
• CAS Number: [1050656-06-8]
• MW: 478.471
• SMILES: O=C(O)C1=CC=C(C2(NC(C3=CC=CC4=C3N(CC5=CC=C(C(F)(F)F)C=C5)C=C4)=O)CC2)C=C1
• Formula: C₂₇H₂₁F₃N₂O₃
• Hazard Information: Non-Toxic
• Note: For research use only
• Expiration Date: 12 months from date of receipt.