Mefuparib hydrochloride(CVL218)

• Catalog Number: orb654533
• Category: Small Molecules
• Description: Mefuparib(CVL218) hydrochloride is a potent, highly selective, competitive PARP1/2 inhibitor with IC50 of 3.2/1.9 nM, respectively.CVL218 was more potent than Remdesivir in blocking Coronavirus infection of cells and equally as potent as Remdesivir in blocking replication of virus once it has entered the cells.
• CAS Number: [1449746-00-2]
• MW: 334.775
• SMILES: O=C(C1=C(OC(C2=CC=C(CNC)C=C2)=C3)C3=CC(F)=C1)N.[H]Cl
• Formula: C₁₇H₁₆ClFN₂O₂
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

References

María Ángeles Márquez-Moñino 1, Clara M Santiveri 2, Patricia de León 3, Sergio Camero 1, Ramón Campos-Olivas 2, M Ángeles Jiménez 1, Margarita Sáiz 3, Beatriz González 4, José Manuel Pérez-Cañadillas The ALS drug riluzole binds to the C-terminal domain of SARS-CoV-2 nucleocapsid protein and has antiviral activity Structure, (2024)

PubMed: 39541975