MC-VC-PABC-C6-alpha-Amanitin

• Catalog Number: orb1942934
• Category: Small Molecules
• Description: MC-VC-PABC-C6-alpha-Amanitin
• CAS Number: 2922514-69-8
• MW: 1616.79
• SMILES: O=S1C2=C(C=3C(N2)=CC(OCCCCCCNC(OCC4=CC=C(NC([C@H](NC([C@H](NC(CCCCCN5C(=O)C=CC5=O)=O)[C@@H](C)C)=O)CCCNC(N)=O)=O)C=C4)=O)=CC3)C[C@@]6(NC(=O)[C@]([C@H]([C@H](CO)O)C)(NC(=O)[C@]7(N(C(=O)[C@H](CC(N)=O)NC(=O)[C@](C1)(NC(=O)CNC(=O)[C@]([C@H](CC)C)(NC(=O)CNC6=O)[H])[H])C[C@H](O)C7)[H])[H])[H]
• Formula: C₇₄H₁₀₅N₁₇O₂₂S
• Biological Activity: MC-VC-PABC-C6-alpha-Amanitin is an antibody-drug conjugate that combines the anticancer toxin alpha-Amanitin with the monoclonal antibody MC-VC-PABC-C6. Alpha-Amanitin acts as a potent inhibitor of RNA polymerase IIα, enabling the conjugate to selectively target and recognize HER2-positive tumor cells. This specificity makes MC-VC-PABC-C6-alpha-Amanitin a valuable research tool in the study of breast and gastric cancers [1].
• Note: For research use only
• Expiration Date: 12 months from date of receipt.