LY487379

• Catalog Number: orb746334
• Category: Small Molecules
• Description: LY-487379 is a potent, selective positive allosteric modulator of mGluR2 (EC50=0.27 uM) without activity at mGluR3; shows no intrinsic agonist or antagonist activity at hmGluR2, markedly potentiates glutamate-stimulated [35S]GTPgammaS binding at hmGluR2; potentiates synaptically evoked mGluR2 responses in rat hippocampal slices, modulates excitatory synaptic transmission in the rat globus pallidus.
• CAS Number: [353231-17-1]
• MW: 452.446
• SMILES: FC(F)(F)CS(N(C1C=CC(OC2C=CC=CC=2OC)=CC=1)CC1=CC=CN=C1)(=O)=O
• Formula: C₂₁H₁₉F₃N₂O₄S
• Note: For research use only
• Expiration Date: 12 months from date of receipt.