LY2811376

• Catalog Number: orb1305231
• Category: Small Molecules
• Description: LY2811376
• CAS Number: 1194044-20-6
• Purity: 99.01%
• MW: 320.36
• SMILES: C[C@]1(C2=CC(=C(F)C=C2F)C=3C=NC=NC3)N=C(N)SCC1
• Formula: C₁₅H₁₄F₂N₄S
• Biological Activity: LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM). It has 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including pepsin, cathepsin D, or renin.
• Storage: Store at -20°C for 12 months.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.