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Catalog Number | orb1089770 |
---|---|
Category | Small Molecules |
Description | Lubiprostone, also known as RU-0211, is a medication used in the management of chronic idiopathic constipation, predominantly irritable bowel syndrome-associated constipation in women and opioid-induced constipation. It was initially approved by the U.S. Food and Drug Administration (FDA) in 2006. Lubiprostone is a bicyclic fatty acid derived from prostaglandin E1 that acts by specifically activating ClC-2 chloride channels on the apical aspect of gastrointestinal epithelial cells, producing a chloride-rich fluid secretion. These secretions soften the stool, increase motility, and promote spontaneous bowel movements (SBM). |
CAS Number | [333963-40-9] |
MW | 390.46 |
SMILES | CCCCC([C@]1(CC[C@@H]2[C@@H](CCCCCCC(=O)O)C(=O)C[C@H]2O1)O)(F)F |
Formula | C20H32F2O5 |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
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