LOXO-305

• Catalog Number: orb746359
• Category: Small Molecules
• Description: LOXO-305 is an investigational, novel, selective non-covalent Bruton’s tyrosine kinase (BTK) inhibitor. LOXO-305 was designed to reversibly bind BTK, preserve activity in the presence of the acquired resistance, and avoid off-target kinases that have complicated the development of both covalent and investigational non-covalent BTK inhibitors.LOXO-305 is a highly selective, non-covalent BTKi that inhibits both wild type (WT) and C481-mutated BTK with equal low nM potency was developed.
• CAS Number: [2101700-15-4]
• MW: 479.436
• SMILES: FC([C@H](C)N1C(=C(C(N)=O)C(C2C=CC(CNC(C3C=C(C=CC=3OC)F)=O)=CC=2)=N1)N)(F)F
• Formula: C₂₂H₂₁F₄N₅O₃
• Note: For research use only
• Expiration Date: 12 months from date of receipt.