LOXO-292 (ARRY-192)

• Catalog Number: orb611903
• Category: Small Molecules
• Description: RET-IN-1 is a RET kinase inhibitor extracted from patent WO2018071447A1, Compound Example 552, has IC50s of 1 nM, 7 nM, and 101 nM for RET (WT), RET (V804M) , and RET (G810R), respectively .
• CAS Number: [2222755-14-6]
• MW: 553.255
• SMILES: N#CC1=C2C(C3=NC=C(N4CC(C5)N(CC6=CC=C(OC)N=C6)C5C4)N=C3)=CC(OC[C@H]7CNCCO7)=CN2N=C1
• Formula: C₂₉H₃₁N₉O₃
• Note: For research use only
• Expiration Date: 12 months from date of receipt.