Lobeline hydrochloride

SKU: orb1226491

Description

Lobeline hydrochloride, a nicotinic receptor agonist, acting as a potent antagonist at both α3β2 and α4β2 neuronal nicotinic receptor subtypes.

Key Properties

• CAS Number: 134-63-4
• MW: 273.92
• Purity: >98% (HPLC)
• Formula: C₂₂H₂₇NO₂·HCl
• SMILES: CN1[C@@H](CC(C2=CC=CC=C2)=O)CCC[C@H]1C[C@H](O)C3=CC=CC=C3.[H]Cl
• Target: AChR
• Solubility: Water: 1g/40mL

Bioactivity

• In Vivo:
  Animal model: Sprague-Dawley rats (200-250 g). Dosage: 0.3 mg/kg, 1.0 mg/kg, and 3.0 mg/kg for acute administration; 3 mg/kg for chronic administration. Administration: Subcutaneous injection; 15 min prior to measurement, or every 15 min for 7 sessions; separated by 2 intervening maintenance days of d-methamphetamine (0.05 mg/kg/infusion) self-administration. Result: Decreased d-methamphetamine Self-Administration.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Lobeline hydrochloride

Quick Database Links

Gene Symbol

AChR