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Catalog Number | orb1298435 |
---|---|
Category | Small Molecules |
Description | KY19382 |
CAS Number | 2226664-93-1 |
Purity | 98.06% |
MW | 360.19 |
SMILES | O=C1C(C=2C(N1)=CC(Cl)=C(Cl)C2)=C3C(=NOC)C=4C(N3)=CC=CC4 |
Formula | C17H11Cl2N3O2 |
Biological Activity | KY19382 (2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-Ky19382) is a potent and orally active dual inhibitor of CXXC5-DVL and GSK3β( IC50s of 19 and 10 nM, respectively). It activates Wnt/β-catenin signaling through inhibitory effects on both CXXC5-DVL interaction and GSK3β activity. KY19382 can be used for the research of high fat diet (HFD) induced metabolic diseases. |
Storage | Store at -20°C for 12 months. |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
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