KRAS inhibitor-9

• Catalog Number: orb1089450
• Category: Small Molecules
• Description: KRAS inhibitor-9, a potent KRAS inhibitor (Kd=92 μM), blocks the formation of GTP-KRAS and downstream activation of KRAS. KRAS inhibitor-9 binds to KRAS G12D, KRAS G12C and KRAS Q61H protein with a moderate binding affinity. KRAS inhibitor-9 causes G2/M cell cycle arrest and induces apoptosis. KRAS inhibitor-9 selectively inhibits the proliferation of NSCLC cells with KRAS mutation but not normal lung cells.
• CAS Number: [300809-71-6]
• MW: 292.8069589
• SMILES: ClC1C([H])=C(C([H])=C([H])C=1SC1=NC2=C([H])C([H])=C([H])C([H])=C2S1)N([H])[H]
• Formula: C₁₃H₉CLN₂S₂
• Note: For research use only
• Expiration Date: 12 months from date of receipt.