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Catalog Number | orb2279720 |
---|---|
Category | Small Molecules |
Description | JP-11646 is a novel potent, selective, non-ATP competitive Pim2 inhibitor with IC50 of 0.5/1/24 nM for Pim2/3/1, respectively; shows less potency for other kinases in a kinase selectivity panel; exhibits 4-760-fold greater suppression of MM proliferation and viability than ATP-competitive PIM inhibitors; significant reduces tumor burden and increases median survival in xenogeneic myeloma murine models. |
CAS Number | [1902983-63-4] |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
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