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Catalog Number | orb1707161 |
---|---|
Category | Small Molecules |
Description | JND3229 |
CAS Number | 2260886-64-2 |
Purity | 98% |
MW | 617.18 |
SMILES | CCC(=O)N[C@H]1CC[C@@H](CC1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1ccccc1Cl |
Formula | C33H41ClN8O2 |
Biological Activity | JND3229 is a reversible EGFRC797S inhibitor with IC50 values of 5.8, 6.8 and 30.5 nM for EGFRL858R/T790M/C797S, EGFRWT and EGFRL858R/T790M, respectively. JND3229 has good anti-proliferative activity and can effectively inhibit tumour growth in vivo. JND3229 can be used in cancer research, especially in non-small cell carcinoma. |
Storage | -20°C |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |