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JND3229

JND3229

Catalog Number: orb1707161

DispatchUsually dispatched within 3-5 working days
$ 160.00
Catalog Numberorb1707161
CategorySmall Molecules
DescriptionJND3229
CAS Number2260886-64-2
Purity98%
MW617.18
SMILESCCC(=O)N[C@H]1CC[C@@H](CC1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(C)CC4)c(C)c3)nc12)c1ccccc1Cl
FormulaC33H41ClN8O2
Biological ActivityJND3229 is a reversible EGFRC797S inhibitor with IC50 values of 5.8, 6.8 and 30.5 nM for EGFRL858R/T790M/C797S, EGFRWT and EGFRL858R/T790M, respectively. JND3229 has good anti-proliferative activity and can effectively inhibit tumour growth in vivo. JND3229 can be used in cancer research, especially in non-small cell carcinoma.
Storage-20°C
NoteFor research use only
Expiration Date12 months from date of receipt.
  • JND3229 [orb573230]

    [2260886-64-2]

    617.184

    C33H41CLN8O2

    1 ml x 10 mm (in DMSO), 100 mg, 250 mg, 1 g