JBJ-09-063 TFA

• Catalog Number: orb1982833
• Category: Small Molecules
• Description: JBJ-09-063 TFA
• MW: 670.67
• Formula: C₃₃H₃₀F₄N₄O₅S
• Biological Activity: JBJ-09-063 TFA is a mutant-selective allosteric EGFR inhibitor, displaying IC50 values of 0.147 nM for EGFR L858R, 0.063 nM for EGFR L858R/T790M, 0.083 nM for EGFR L858R/T790M/C797S, and 0.396 nM for EGFR L747S mutations. It effectively reduces phosphorylation of EGFR, Akt, and ERK1/2, demonstrating efficacy in models sensitive and resistant to EGFR tyrosine kinase inhibitors (TKI). JBJ-09-063 TFA holds potential for research in EGFR-mutant lung cancer [1].
• Note: For research use only
• Expiration Date: 12 months from date of receipt.