JBJ-09-063

• Catalog Number: orb1686101
• Category: Small Molecules
• Description: JBJ-09-063
• CAS Number: 2820336-67-0
• Purity: 98%
• MW: 556.65
• SMILES: C(C(NC1=NC=CS1)=O)(N2C(=O)C=3C(C2)=CC=C(C3)C4=CC=C(C=C4)C5CCN(C)CC5)C6=C(O)C=CC(F)=C6
• Formula: C₃₁H₂₉FN₄O₃S
• Biological Activity: JBJ-09-063 is a mutation-selective variant EGFR inhibitor that acts on EGFR L858R (IC50: 0.147 nM), EGFR L858R/T790M (IC50: 0.063 nM), EGFR L858R/T790M/C797S (IC50: 0.083 nM) and EGFRLT/L747S (IC50: 0.396 nM). JBJ-09-063 is effective in both EGFR tyrosine kinase inhibitor (TKI)-sensitive and resistant models.JBJ-09-063 is effective in reducing EGFR, Akt and ERK1/2 phosphorylation.JBJ-09-063 can be used to study EGFR mutant lung cancer.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.