JBJ-09-063 hydrochloride

• Catalog Number: orb1745035
• Category: Small Molecules
• Description: JBJ-09-063 hydrochloride
• MW: 593.11
• SMILES: CN1CCC(CC1)C2=CC=C(C=C2)C3=CC4=C(CN(C4=O)C(C5=C(C=CC(=C5)F)O)C(=O)NC6=NC=CS6)C=C3.Cl
• Formula: C₃₁H₃₀ClFN₄O₃S
• Biological Activity: JBJ-09-063 hydrochloride is an EGFR inhibitor selective for mutants, demonstrating IC50 values of 0.147 nM, 0.063 nM, 0.083 nM, and 0.396 nM against EGFR L858R, EGFR L858R/T790M, EGFR L858R/T790M/C797S, and EGFR L747S, respectively. It effectively inhibits EGFR, Akt, and ERK1/2 phosphorylation, showing efficacy in both EGFR tyrosine kinase inhibitor (TKI)-sensitive and -resistant models. This compound holds potential for research on EGFR-mutant lung cancer.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.