IWP-2

• Catalog Number: orb1305145
• Category: Small Molecules
• Description: IWP-2
• CAS Number: 686770-61-6
• Purity: 99.76%
• MW: 466.6
• SMILES: Cc1ccc2nc(NC(=O)CSc3nc4CCSc4c(=O)n3-c3ccccc3)sc2c1
• Formula: C₂₂H₁₈N₄O₂S₃
• Biological Activity: IWP-2, an inhibitor of Wnt processing and secretion (IC50=27 nM) in a cell-free assay, selectively blocks Porcn-mediated Wnt palmitoylation.
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

References

Qingnian Liu 1, Jiniu Huang 1, Hao Ding 1, Yue Tao 1, Jinliang Nan 1, Changchen Xiao 1, Yingchao Wang 1, Rongrong Wu 1, Cheng Ni 1, Zhiwei Zhong 1, Wei Zhu 2, Jinghai Chen 3, Chenyun Zhang 1, Xiao He 4, Danyang Xiong 4, Xinyang Hu 1, Jian'an Wang Flavin-containing monooxygenase 2 confers cardioprotection in ischemia models through its disulfide-bond catalytic activity J Clin Invest, (2024)

PubMed: 39480513