IU1-47

• Catalog Number: orb757619
• Category: Small Molecules
• Description: IU1-47 is a potent, selective small-molecule inhibitor of USP14 with IC50 of 0.6 uM, shows 10-fold more potent over IU1 and retains specificity for USP14; accelerates the rate of degradation of wild-type tau, the pathological tau mutants P301L and P301S, and the A152T tau variant in primary neuronal cultures, a specific residue in tau, lysine 174, is critical for the IU1-47-mediated tau degradation by the proteasome; stimulates autophagic flux in primary neurons.
• CAS Number: [670270-31-2]
• MW: 330.856
• SMILES: CC1=CC(C(CN2CCCCC2)=O)=C(C)N1C3=CC=C(Cl)C=C3
• Formula: C₁₉H₂₃ClN₂O
• Note: For research use only
• Expiration Date: 12 months from date of receipt.