IR-Crizotinib

• Catalog Number: orb1942717
• Category: Small Molecules
• Description: IR-Crizotinib is a conjugate of the near-infrared dye IR-786 and Crizotinib, an NF-κB-inducing kinase (NIK) inhibitor, with an IC50 of 3.381 μM for intracranial glioblastoma (GBM) localization in mice. It has the ability to cross the blood-brain barrier and fluorescently mark GBM, and demonstrates efficacy in inhibiting glioma proliferation and invasion both in vitro and in vivo, making it significant in cancer research [1].
• CAS Number: 2387927-74-2
• Purity: 98.00%
• MW: 1024.88
• SMILES: C(\C=C\1/C(C)(C)C=2C(N1C)=CC=CC2)=C\3C(=C(/C=C/C=4C(C)(C)C=5C([N+]4C)=CC=CC5)CCC3)N6CCC(CC6)N7C=C(C=N7)C=8C=C(O[C@H](C)C9=C(Cl)C(F)=CC=C9Cl)C(N)=NC8.[I-]
• Formula: C₅₃H₅₇Cl₂FIN₇O
• Biological Activity: IR-Crizotinib is a conjugate of the near-infrared dye IR-786 and Crizotinib, an NF-κB-inducing kinase (NIK) inhibitor, with an IC50 of 3.381 μM for intracranial glioblastoma (GBM) localization in mice. It has the ability to cross the blood-brain barrier and fluorescently mark GBM, and demonstrates efficacy in inhibiting glioma proliferation and invasion both in vitro and in vivo, making it significant in cancer research [1].
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.