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Integrin alpha V beta 8 Protein, Human, Recombinant (His)
Catalog Number: orb1954182
| Catalog Number | orb1954182 |
|---|---|
| Category | Proteins |
| Description | Integrin alpha V beta 8 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligands. ITGAVB8 does not appear to assume different activation states; and the cytoplasmic tail does not connect to the cytoskeleton. It binds ligands containing an RGD motif; including vitronectin; fibrin and the latency associated peptide (LAP) of the latent TGF-beta complex. High affinity binding of alpha V beta 8 to LAP allows proteolytic cleavage by MT1-MMP; which releases active TGF-beta. This mechanism differs from that of alpha V beta 6; the other alpha V integrin which can activate TGF-beta from latency through non-proteolytic mechanisms. |
| Tag | C-His |
| Purity | SDS-PAGE: 97.1%; SEC-HPLC: 96.8% |
| MW | 187.95 kDa (predicted) |
| UniProt ID | P26012, P06756 |
| Expression System | HEK293 Cells |
| Biological Origin | Human |
| Biological Activity | Integrin alpha V beta 8 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligands. ITGAVB8 does not appear to assume different activation states; and the cytoplasmic tail does not connect to the cytoskeleton. It binds ligands containing an RGD motif; including vitronectin; fibrin and the latency associated peptide (LAP) of the latent TGF-beta complex. High affinity binding of alpha V beta 8 to LAP allows proteolytic cleavage by MT1-MMP; which releases active TGF-beta. This mechanism differs from that of alpha V beta 6; the other alpha V integrin which can activate TGF-beta from latency through non-proteolytic mechanisms. |
| Expression Region | A DNA sequence encoding the extracellular domain (Met1-Val992) of human ITGAV (P06756) was fused with a C-terminal polyhistidine tag was expressed., constructed the plasmid 1; A DNA sequence encoding the extracellular domain (Met1-Arg684) of human ITGB8 (P26012) constructed the plasmid 2. The two plasmids were co-expressed and the human ITGAV&ITGB8 heterodimer was purified. Predicted N terminal: Phe31 & Glu43 |
| Storage | -20°C |
| Note | For research use only |
| Application notes | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
| Expiration Date | 6 months from date of receipt. |
