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IL-7 Protein, Human, Recombinant (His)

IL-7 Protein, Human, Recombinant (His)

Catalog Number: orb1962154

DispatchUsually dispatched within 5-10 working days
$ 220.00
Catalog Numberorb1962154
CategoryProteins
DescriptionHuman Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL7 can associate with the hepatocyte growth factor (HGF) to form a hybrid cytokine that functions as a pre-pro-B cell growth-stimulating factor. Human IL7 cDNA encodes a 177 amino acid precursor protein containing a 25 amino acid signal peptide and a 152 amino acid mature protein. Human and mouse IL7 share 65% sequence identity in the mature region and both exhibit cross-species activity. IL-7 signals via IL-7 receptor (IL7R) activating multiple pathways including JaK/STAT and PI3K/AKT, which regulate lymphocyte survival, glucose uptake, proliferation, and differentiation. IL-7 is also associated with cytoplasmic IL2-R gamma for signal transduction.
TagC-6xHis
Purity> 99.9%
MW19-30 KDa (reducing condition)
UniProt IDP13232
Protein SequenceAsp26-His177
Expression SystemHEK293 Cells
Biological OriginHuman
Biological ActivityHuman Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL7 can associate with the hepatocyte growth factor (HGF) to form a hybrid cytokine that functions as a pre-pro-B cell growth-stimulating factor. Human IL7 cDNA encodes a 177 amino acid precursor protein containing a 25 amino acid signal peptide and a 152 amino acid mature protein. Human and mouse IL7 share 65% sequence identity in the mature region and both exhibit cross-species activity. IL-7 signals via IL-7 receptor (IL7R) activating multiple pathways including JaK/STAT and PI3K/AKT, which regulate lymphocyte survival, glucose uptake, proliferation, and differentiation. IL-7 is also associated with cytoplasmic IL2-R gamma for signal transduction.
Expression RegionAsp26-His177
Storage-20°C
NoteFor research use only
Application notesReconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Expiration Date6 months from date of receipt.
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    > 95% as determined by Tris-Bis PAGE; > 95% as determined by SEC-HPLC

    Due to glycosylation, the protein migrates to 50-60 kDa based on Tris-Bis PAGE result. kDa

    100 μg, 50 μg
  • Recombinant human IL-7R Alpha / CD127 protein, His (HEK293) [orb1516641]

    > 95% as determined by SDS-PAGE

    40-70 kDa

    100 μg, 500 μg
  • IL-7 Protein, Mouse, Recombinant (His) [orb1962173]

    > 99.9%

    22-28 KDa (reducing condition)

    1 mg, 500 μg, 10 μg, 50 μg
  • Human IL 7 (His) Protein [orb426537]

    Greater than 95.0% as determined by SDS-PAGE.

    Escherichia Coli

    1 mg, 2 μg, 10 μg
  • Recombinant Human IL-7 Protein, His Tag [orb1550704]

    > 90% by SDS-PAGE.

    Recombinant Human IL-7 Protein is produced by HEK293 Cells expression system. The target protein is expressed with sequence (Asp26-His Tag177) of human IL-7 (Accession #NP_000871.1) fused with a 6��His Tag at the C-terminus.

    100 μg, 50 μg