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IL-7 Protein, Human, Recombinant (His)
Catalog Number: orb1962154
| Catalog Number | orb1962154 |
|---|---|
| Category | Proteins |
| Description | Human Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL7 can associate with the hepatocyte growth factor (HGF) to form a hybrid cytokine that functions as a pre-pro-B cell growth-stimulating factor. Human IL7 cDNA encodes a 177 amino acid precursor protein containing a 25 amino acid signal peptide and a 152 amino acid mature protein. Human and mouse IL7 share 65% sequence identity in the mature region and both exhibit cross-species activity. IL-7 signals via IL-7 receptor (IL7R) activating multiple pathways including JaK/STAT and PI3K/AKT, which regulate lymphocyte survival, glucose uptake, proliferation, and differentiation. IL-7 is also associated with cytoplasmic IL2-R gamma for signal transduction. |
| Tag | C-6xHis |
| Purity | > 99.9% |
| MW | 19-30 KDa (reducing condition) |
| UniProt ID | P13232 |
| Protein Sequence | Asp26-His177 |
| Expression System | HEK293 Cells |
| Biological Origin | Human |
| Biological Activity | Human Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL7 can associate with the hepatocyte growth factor (HGF) to form a hybrid cytokine that functions as a pre-pro-B cell growth-stimulating factor. Human IL7 cDNA encodes a 177 amino acid precursor protein containing a 25 amino acid signal peptide and a 152 amino acid mature protein. Human and mouse IL7 share 65% sequence identity in the mature region and both exhibit cross-species activity. IL-7 signals via IL-7 receptor (IL7R) activating multiple pathways including JaK/STAT and PI3K/AKT, which regulate lymphocyte survival, glucose uptake, proliferation, and differentiation. IL-7 is also associated with cytoplasmic IL2-R gamma for signal transduction. |
| Expression Region | Asp26-His177 |
| Storage | -20°C |
| Note | For research use only |
| Application notes | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Expiration Date | 6 months from date of receipt. |
- Item 1 of 2
Recombinant human IL-7R Alpha / CD127 protein, C-His (HEK293) [orb1516415]
> 95% as determined by Tris-Bis PAGE; > 95% as determined by SEC-HPLC
Due to glycosylation, the protein migrates to 50-60 kDa based on Tris-Bis PAGE result.
100 μg, 50 μg - Item 1 of 1
Recombinant human IL-7R Alpha / CD127 protein, His (HEK293) [orb1516641]
> 95% as determined by SDS-PAGE
40-70 kDa
100 μg, 500 μg IL-7 Protein, Mouse, Recombinant (His) [orb1962173]
> 99.9%
22-28 KDa (reducing condition)
1 mg, 500 μg, 10 μg, 50 μgHuman IL 7 (His) Protein [orb426537]
Greater than 95.0% as determined by SDS-PAGE.
Escherichia Coli
1 mg, 2 μg, 10 μgRecombinant Human IL-7 Protein, His Tag [orb1550704]
> 90% by SDS-PAGE.
Recombinant Human IL-7 Protein is produced by HEK293 Cells expression system. The target protein is expressed with sequence (Asp26-His Tag177) of human IL-7 (Accession #NP_000871.1) fused with a 6��His Tag at the C-terminus.
100 μg, 50 μg
