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IL-7 Protein, Human, Recombinant (His)
Catalog Number: orb1962154
| Catalog Number | orb1962154 |
|---|---|
| Category | Proteins |
| Description | Human Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL7 can associate with the hepatocyte growth factor (HGF) to form a hybrid cytokine that functions as a pre-pro-B cell growth-stimulating factor. Human IL7 cDNA encodes a 177 amino acid precursor protein containing a 25 amino acid signal peptide and a 152 amino acid mature protein. Human and mouse IL7 share 65% sequence identity in the mature region and both exhibit cross-species activity. IL-7 signals via IL-7 receptor (IL7R) activating multiple pathways including JaK/STAT and PI3K/AKT, which regulate lymphocyte survival, glucose uptake, proliferation, and differentiation. IL-7 is also associated with cytoplasmic IL2-R gamma for signal transduction. |
| Tag | C-6xHis |
| Purity | 98.00% |
| MW | 19-30 KDa (reducing condition) |
| UniProt ID | P13232 |
| Protein Sequence | Asp26-His177 |
| Expression System | HEK293 Cells |
| Biological Origin | Human |
| Biological Activity | Human Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL7 can associate with the hepatocyte growth factor (HGF) to form a hybrid cytokine that functions as a pre-pro-B cell growth-stimulating factor. Human IL7 cDNA encodes a 177 amino acid precursor protein containing a 25 amino acid signal peptide and a 152 amino acid mature protein. Human and mouse IL7 share 65% sequence identity in the mature region and both exhibit cross-species activity. IL-7 signals via IL-7 receptor (IL7R) activating multiple pathways including JaK/STAT and PI3K/AKT, which regulate lymphocyte survival, glucose uptake, proliferation, and differentiation. IL-7 is also associated with cytoplasmic IL2-R gamma for signal transduction. |
| Expression Region | Asp26-His177 |
| Storage | -20°C |
| Note | For research use only |
| Application notes | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Expiration Date | 6 months from date of receipt. |
Recombinant Human IL-7 Protein, His Tag [orb1550704]
> 90% by SDS-PAGE.
KMP1785, Recombinant Human IL-7 Protein is produced by HEK293 Cells expression system. The target protein is expressed with sequence (Asp26-His Tag177) of human IL-7 (Accession #NP_000871.1) fused with a 6×His Tag at the C-terminus.
50 μg, 100 μgHuman IL-7R Alpha Protein [orb1516415]
> 95% as determined by Tris-Bis PAGE; > 95% as determined by SEC-HPLC
Due to glycosylation, the protein migrates to 50-60 kDa based on Tris-Bis PAGE result. kDa
Human IL-7R Alpha Protein [orb1516641]
> 95% as determined by SDS-PAGE
40-70 kDa
Recombinant Human IL7 Protein, His Tag [orb1553505]
≥90% as determined by SDS-PAGE
This protein contains the human IL7(Asp26-His177) was fused with the C-terminal His Tag and expressed in E. coli.
50 μg, 100 μg
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