IL-6R antibody

• Catalog Number: orb758841
• Category: Antibodies
• Description: Rabbit monoclonal antibody to IL-6R
• Species/Host: Rat
• Clonality: Monoclonal
• Clone Number: D7715A7
• Tested applications: Blocking, FC
• Reactivity: Mouse
• Isotype: IgG
• Immunogen: This antibody was raised by immunising Lewis rats with OKT4 cells.
• Concentration: 1 mg/ml
• Purity: Purified
• Conjugation: Unconjugated
• Target: IL-6R
• UniProt ID: P22272
• Storage: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
• Buffer/Preservatives: PBS with 0.02% Proclin 300.
• Alternative names: CD126; 15A7; IL-6Ra; IL6R; Interleukin-6 receptor
• Note: For research use only
• Application notes: This antibody binds to IL-6R-positive cells, and blocks IL-6 binding (Vink et al, 1990; Coulie et al, 1990). This antibody is able to inhibit the growth of IL6-dependent plasmacytoma T1033C2 in vitro (Coulie et al, 1990). Administration of this antibody to mice prior to challenge with T1033C2 resulted in a protection rate of 60% and prolonged survival in tumour-bearing mice (Vink et al, 1990). This antibody has been used in flow cytometry to assess IL-6Ra expression (Hoge et al, 2013). When added to dendritic cells subject to CD40 activation in vitro, this antibody neutralises IL-6 and ablates the effect of CD40 activation (Grohmann et al, 2001).
• Expiration Date: 12 months from date of receipt.