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IL-25 Antibody / IL-17E
Catalog Number: orb2635111
| Catalog Number | orb2635111 |
|---|---|
| Category | Antibodies |
| Description | Cytokines are small, soluble proteins with pleiotropic effects on a variety of cell types. Cytokines have a regulatory function over the immune system and mediate aspects of inflammatory response. They exert their biological effects through the binding of membrane-bound receptors which, in turn, initiate signal transduction cascades and elicit physiological changes in their target cell. Interleukin-17 (IL-17) and its cognate receptor, IL-17R, are an example of such a cytokine receptor pair. Originally identified as a rodent cDNA termed CTLA8, IL-17 is capable of inducing the secretion of IL-6 and IL-8 and augmenting the expression of ICAM-1 in human fibroblast cultures. The IL-17 protein exhibits a striking degree of homology with the HSV-13 protein which mimics its function. The IL-17 receptor is a type I transmembrane protein 864 amino acids in length that is highly expressed in spleen and kidney. |
| Species/Host | Mouse |
| Clonality | Monoclonal |
| Clone Number | IL25/625 |
| Tested applications | IHC-P |
| Reactivity | Human |
| Isotype | Mouse IgG1, kappa |
| Immunogen | A recombinant protein fragment was used as the immunogen for the IL-25 antibody. |
| Antibody Type | Primary Antibody |
| Dilution range | Immunohistochemistry (FFPE): 1-2ug/ml |
| Conjugation | Unconjugated |
| Formula | 1 mg/ml in 1X PBS; BSA free, sodium azide free |
| Hazard Information | This IL-25 antibody is available for research use only. |
| UniProt ID | Q9H293 |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Note | For research use only |
| Application notes | Optimal dilution of the IL-25 antibody should be determined by the researcher. |
| Expiration Date | 12 months from date of receipt. |
IHC staining of FFPE human colon carcinoma tissue with IL-25 antibody (clone IL25/625). HIER: boil tissue sections in pH9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
IHC staining of FFPE human adrenal gland tissue with IL-25 antibody (clone IL25/625). HIER: boil tissue sections in pH9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
SDS-PAGE analysis of purified, BSA-free IL-25 antibody (clone IL25/625) as confirmation of integrity and purity.
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