IL-18R alpha Protein, Cynomolgus, Recombinant (aa 22-329, His)

• Catalog Number: orb1960385
• Category: Proteins
• Description: Interleukin-18 (IL-18) is a member of the interleukin-1 family of cytokines produced constitutively by different cell types and by adipose tissue. Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag plus IL-12, naïve T cells develop into IL-18 receptor (IL-18R) expressing Th1 cells, which increase IFN-γ production in response to IL-18 stimulation. IL-18R alpha Protein, Cynomolgus, Recombinant (aa 22-329, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 36.45 kDa and the accession number is A0A2K5V3J9.
• Tag: C-His
• Purity: 98.00%
• MW: 36.45 kDa (predicted). Due to glycosylation, the protein migrates to 60-70 kDa based on Tris-Bis PAGE result.
• UniProt ID: A0A2K5V3J9
• Expression System: HEK293 Cells
• Biological Origin: Cynomolgus
• Biological Activity: Interleukin-18 (IL-18) is a member of the interleukin-1 family of cytokines produced constitutively by different cell types and by adipose tissue. Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag plus IL-12, naïve T cells develop into IL-18 receptor (IL-18R) expressing Th1 cells, which increase IFN-γ production in response to IL-18 stimulation. IL-18R alpha Protein, Cynomolgus, Recombinant (aa 22-329, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 36.45 kDa and the accession number is A0A2K5V3J9.
• Expression Region: Cys22-Gly329
• Storage: -20°C
• Note: For research use only
• Application notes: Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
• Expiration Date: 6 months from date of receipt.