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Catalog Number | orb1962167 |
---|---|
Category | Proteins |
Description | Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. Today, IL-17 represents a family of structurally related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17F also regulates cartilage matrix turnover and inhibits angiogenesis. |
Tag | Tag Free |
Purity | 98.00% |
MW | 15 KDa (reducing condition) |
UniProt ID | Q96PD4 |
Protein Sequence | Arg31-Gln163 |
Expression System | E. coli |
Biological Origin | Human |
Biological Activity | Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. Today, IL-17 represents a family of structurally related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17F also regulates cartilage matrix turnover and inhibits angiogenesis. |
Expression Region | Arg31-Gln163 |
Storage | -20°C |
Note | For research use only |
Application notes | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
Expiration Date | 6 months from date of receipt. |
Greater than 95% as determined by SDS-PAGE. | |
14.9 kDa | |
E.coli |
Greater than 95% as determined by SDS-PAGE. | |
15.96 kDa | |
Mammalian cell |
> 95% as determined by SDS-PAGE and HPLC. | |
15 kDa | |
E.Coli |
The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining. | |
The protein has a predicted molecular mass of 15.7 kDa after removal of the signal peptide. The apparent molecular mass of His-IL17F is approximately 15-25 kDa due to glycosylation. | |
Mammalian |